The genetic effect involved in preganant glucose meatabolism, especially the genetic predisposition for gestational diabetes is clinically significant and poses risk of Type 2 diabetes. We search the genetic effect on gestational glucose homeostasis and dissect its molecular regulation.

Publications:

1.         Liu Y, Lu Y, Liu S, Liao S*. Novel compound heterozygous mutations of ALDH1A3 contribute to anophthalmia in a non-consanguineous Chinese family. Genet Mol Biol. 2017; 40(2):430-435.

2.         Lu Y, Liu Y, Liao S, Tu W, Shen Y, Yan Y, Tao D, Lu Y, Ma Y, Yang Y, Zhang S. Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells. Oncotarget. 2016 12;7(28):43162-43176.

3.         Liao S*, Liu Y, Chen X, Tan Y, Mei J, Song W, Gan L, Wang H, Yin S, Dong X, Chi S, Deng S*. The Impact of Genetic Variants for Different Physiological Characterization of Type 2 Diabetes Loci on Gestational Insulin Signaling in Nondiabetic Pregnant Chinese Women. Reprod Sci. 2015; 22(11):1421-8. Apr 14.

4.         Mei J, Liao S*, Liu Y, Tan Y, Wang H, Liang Y, Dong X, Song W, Gan L, Deng S*. Association of variants in CDKN2A/2B and CDKAL1 genes with gestational insulin sensitivity and disposition in pregnant Han Chinese Women, Journal of Diabetes Investigation 2015; 6(3):295-301.

5.         Liao S, Mei J, Song W, Liu Y, Tan YD, Chi S, Li P, Chen X, Deng S*. The impact of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) fasting glucose diagnostic criterion on the prevalence and outcomes of gestational diabetes mellitus in Han Chinese women. Diabet Med. 2014 Mar; 31(3):341-51.

6.         Liao S*, Song W*, Liu Y, Deng S, Liang Y, Tang Z, Huang J, Dong D, Xu G. Familial multinodular goiter syndrome with papillary thyroid carcinomas: mutational analysis of the associated genes in 5 cases from 1 Chinese family. BMC Endocr Disord. 2013 21; 13(1):48.

7.         Liu YQ, Tao DC, Liao S, Yang Y, Ma YX, Zhang SZ. Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. Genet Mol Res. 2013 27; 12(3):4060-9.

8.         Liao S*, Liu Y, Tan Y, Gan L, Mei J, Song W, Chi S, Dong X, Chen X, Deng S*. Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women. PLoS One. 2012; 7(7): e40113.

9.         Liao S, Liu Y, Zheng B, Cho PY, Song HO, Lee YS, Jung SY, Park H.　Expression of exogenous human hepatic nuclear factor-1α by a lentiviral vector and its interactions with Plasmodium falciparum subtilisin-like protease 2. Korean J Parasitol. 2011; 49(4):431-6.

10.     Liao S, Liu Y, Jung SY, Cho PY, Zheng B, Park H. Transcriptional activity of Plasmodium subtilisin-like protease 2 (Pf-Sub2) 5'untranslated regions and its interaction with hepatocyte growth factor. Korean J Parasitol. 2010; 48(4):291-5.

11.     Wiznerowicz M, Jakobsson J, Szulc J, Liao S, Quazzola A, Beermann F, Aebischer P, Trono D. The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis. J Biol Chem. 2007 Nov 23; 282(47):34535-41.

12.     Mangeat B, Turelli P, Liao S, Trono D. A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action. J Biol Chem. 2004 9; 279(15):14481-3.