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    魏亮

    • 性别:男
    • 毕业院校:四川大学
    • 学历:博士研究生毕业
    • 学位:医学博士学位
    • 在职信息:在岗
    • 所在单位:医学院
    • 学科:生物医学工程

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    个人简介

    四川省高层次特聘专家、成都“蓉漂计划”特聘专家、四川省医学会器官移植专委会常委,四川省医学会转化医学专委会常委,美国器官移植学会会员,成都欧美同学会常务理事,成都高新区金熊猫人才。2009年博士毕业于四川大学华西临床医学院移植科学与工程学专业,2009年10月至2013年12月在美国斯坦福大学器官移植中心从事移植免疫相关的博士后研究工作,共发表SCI论文20余篇,发明专利十余项,以第一作者身份在器官移植领域知名杂志Am J Transplant、Transplantation等上发表学术成果,被引用300余次。多次担任美国斯坦福大学SIMR项目导师,培养学生被斯坦福、加州理工等大学录用。作为项目负责人承担国家自然科学基金、四川省科技支撑计划项目等,作为参研人员参与国家科技部973项目、科技部重点研发项目、美国NIH项目、美国AHA项目等,作为主编助理和作者编写“十一五规划”研究生教材一部。在美期间负责美国生物制药公司的新型免疫抑制剂研发工作,担任美国硅谷生物信息科技公司咨询总监,多次获得器官移植、免疫学领域的国际学术奖励,2014年获得世界器官移植学会颁发的优秀青年学者奖。在移植术后新型诊断技术、移植免疫排斥机理和移植免疫耐受诱导领域,具有丰富的学术背景和研究经历,重视对研究生科学思维和应用能力的培养,强调科学研究的应用转化价值。


    学术论文

     


    Wei L, Wang M, Qu X, Mah A, Xiong X, Harris AG, Phillips LK, Martinez OM, Krams SM. Differential expression of microRNAs during allograft rejection. American Journal of Transplantation. 2012; 12 (5): 1113-23.

    Wei L, Kaul V, Qu X, Xiong X, Lau A, Iwai N, Martinez O, Krams S. Absence of miR-182 Augments Cardiac Allograft Survival. Transplantation. 2017;101(3):524-530.

    Vitalone M, Wei L, Fujiki M, Lau A, Littau E, Esquivel C, Martinez O, Krams S. Liver microRNA profile of induced allograft tolerance. Transplantation. 2016; 100: 781-90.

    Furukawa S, Wei L, Krams SM, Esquivel CO, Martinez OM. PI3K Inhibition Augments the Efficacy of the mTOR Inhibitor Rapamycin in Suppressing Proliferation of Epstein-Barr Virus (EBV)+ B Cell Lymphomas. American Journal of Transplantation. 2013; 13(8):2035-43.

    Fu Q, Yang F, Zhao J, Yang X, Xiang T, Huai G, Zhang J, Wei L, Deng S, Yang H. Bioinformatical identification of key pathways and genes in human hepatocellular carcinoma after csn5 depletion[J]. Cellular signalling, 2018, 49(79-86.

    Fu Q, Yang F, Xiang T, Huai G, Yang X, Wei L, Yang H, Deng S. A novel microrna signature predicts survival in liver hepatocellular carcinoma after hepatectomy. Scientific reports, 2018, 8(1):7933.

    Huang L, Li F, Fu Q, Yang X, Deng S, Wei L#. Role of miR-449a in the Activation and Metabolism of CD4(+) T Cells. Transplant Proc, 2018, 50(5): 1519-1524.

    Li F, Qian W, Quan X, Yang H, Zhao G, Wei L#. Differential miRNA expressions in human peripheral blood mononuclear cells are predictive of renal allograft function. Transplant Proc, 2019, 51(3):715-721.

    Wei L, Gong X, Martinez OM, Krams SM. Differential expression and functions of microRNAs in liver transplantation and potential use as non-invasive biomarkers. Transplant Immunology. 2013; 29:123-9.

    Wei L, Lu J, Feng L, Long D, Shan J, Li S, Li Y. HIF-1α accumulation upregulates MICA and MICB expression on human cardiomyocytes and enhances NK cell cytotoxicity during hypoxia-reoxygenation. Life Sciences. 2010, 87:111-9.

    Wei L, Lu J, Feng L, Li S, Shan J, Li Y. Construction of recombinant adenovirus vector containing a modified gene that codes for human hypoxia-inducible factor-1alpha without oxygen-dependent degradation domain. Plasmid. 2010, 63(1):20-6.

    Xiong X, Xu L, Wei L, White RE, Ouyang YB, Giffard RG. IL-4 Is Required for Sex Differences in Vulnerability to Focal Ischemia in Mice. Stroke. 2015; 46(8):2271-6.

    Zhuo M, Fujiki M, Wang M, Piard-Ruster K, Wai LE, Wei L, Martinez OM, Krams SM. Identification of the Rat NKG2D Ligands, RAE1L and RRLT and Their Role in Allograft Rejection. European Journal of Immunology. 2010, 40:1748-57.

    Luo L, Lu J, Wei L, Long D, Guo YJ, Shan J, Li FS, Lu PY, Li PY, Feng L. The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation. BMC Cell Biology. 2010, 11:91.

    Lu J, Luo L, Guo YJ, Long D, Wei L, Shan J, Feng L, Li SF, Yang XY, Lu YP, Krams S, Li YP. The effect of MICA antigens on transplant outcomes: A systematic review. Journal of Evidence-Based Medicine. 2011, 4 (2): 106-121.

    Feng L, Guo Y, Cheng F, Li S, Wei L, Long D, Li Q, Li Y. Effects of pretreatment with Yisheng injection on renal warm ischemia/reperfusion injury in mice. Transplantation Proceedings. 2010, 42:1545-9.

    Feng L, Pang L, Guo Y, Ke N, Li S, Wei L, Li Q, Li Y. Hypoxia/reoxygenation up-regulates death receptor expression and enhances apoptosis in human biliary epithelial cells. Life Sciences. 2009, 85(9-10):401-7.

    Wei L, Cao Y, Bai L, Liang X, Deng T, Li J, Qiao D. Cloning and expression of a gene coding for the major light-harvesting chlorophyll a/b protein of photosystem II in the green alga Dunaliella salina. J Appl Phycol, 2007, 19:89-94.

    Wei L, Cao Y, Liang X, Liu Y, Deng T, Bai L, Qiao D. Identification of two genes encoding the major light-harvesting chlorophyll a/b proteins of photosystem II in green alga Dunaliella salina. DNA seq, 2006, 17:370-7.

    Liang X, Qiao D, Huang M, Yi X, Bai L, Xu H, Wei L, Zeng J, Cao Y. Identification of a gene encoding the light-harvesting chlorophyll a/b proteins of photosystem I in green alga Dunaliella salina. DNA Seq, 2008, 19:137-45.

    He Q, Qiao D, Zhang Q, Li Y, Xu H, Wei L, Gu Y, Cao   Y. Cloning and expression study of a putative high-affinity nitrate transporter gene from Dunaliella salina. J Appl Phycol, 2004, 16:395-400.

     



    工作经历

    2014.5 -- 至今

    四川省医学科学院·四川省人民医院      器官移植研究所

    社会兼职

  • 2017.1 -- 至今

    中华医学会四川分会器官移植专委会  常务委员

  • 研究方向

  • 基于机器学习算法的新型诊断模型

  • 器官移植免疫耐受诱导机制

  • 胰岛的能量代谢调控机制

  • 器官移植的免疫调节分子机制