Affiliation of Author(s):[1]North Sichuan Med Coll, Affiliated Hosp, Nanomed Innovat Res & Transformat Inst, Nanchong 637000, Peoples R China;[2]Southwest Minzu Univ, Sch Chem & Environm, Key Lab Gen Chem Natl Ethn Affairs Commiss, Chengdu 610041, Peoples R China;[3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Pharm, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Peoples R China;[4]Chengdu Univ, Coll Food & Biol Engn, Chengdu 610106, Peoples R China
Journal:ADVANCED FUNCTIONAL MATERIALS
Key Words:blood-brain barrier; nanozymes; neurological diseases; oxidoreductase mimicry; reactive nitrogen species; reactive oxygen species
Abstract:The prevalence of neurological dieases, including neurodegenerative, neurotraumatic disorders, and neuroinflammatory conditions, has been rising due to global population and aging demographics. A key factor in the pathogenesis of these disorders is the hyperaccumulation of reactive oxygen and nitrogen species (RONS). Nanozymes have emerged as promising candidates for neurotherapeutic applications owing to their exceptional catalytic activity and stability. Of particular note is their ability to cross the blood-brain barrier and counteract the production of reactive oxygen species via their enzyme-mimicking characteristics. In this review, the latest advancements and theoretical knowledge in this research domain are summarized. Using the inherent functionalities of the Web of Science and bibliometric methodologies, annual publication trends are identified and extensively explored the most researched topics and neurological disorders in this field. The antioxidant reduction chemistry of the nanozymes is discussed, highlighting their ability to mimic natural oxidoreductase activity and inhibit RONS production at the source. Moreover, this review delves into the current limitations and future prospects of these mechanisms in addressing neurological disorders. The significant benefits and recent developments in the use of RONS-regulating nanozymes for the treatment of neurological diseases are emphasized, offering insights into their therapeutic applications and broader implications for neurology. Illustration summarizes the application of nanozymes in treating various neurological diseases, including Alzheimer's disease, Parkinson's disease, stroke, traumatic brain injury, epilepsy, and spinal cord injury. Highlights the role of nanozymes in crossing the blood-brain barrier, mimicking antioxidant enzymes, and regulating reactive oxygen and nitrogen species to mitigate oxidative stress and inflammation. image
Document Type:Review
Volume:34
Issue:39
ISSN No.:1616-301X
Translation or Not:no