Affiliation of Author(s):[1]Hosp Univ Elect Sci & Technol China, Dept Pharm, Chengdu 610072, Peoples R China;[2]Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R China;[3]Sichuan Univ, Sch Life Sci, Chengdu 610041, Peoples R China;[4]Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China;[5]Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Journal:MOLECULAR BIOSYSTEMS
Abstract:Arctigenin (ARG) has been previously reported to exert diverse biological activities including anti-proliferation, anti-inflammatory, and antiviral, etc. In the current study, the anti-metastasis and anti-angiogenesis activities of ARG were investigated. To further understand how ARG played these bioactivities, proteomic approaches were used to profile the proteome changes in response to ARG treatment using 2DE-MS/MS. Using these approaches, a total of 50 differentially expressed proteins were identified and clustered. Bioinformatics analysis suggested that multiple signalling pathways were involved. Moreover, ARG induced anti-metastatic and anti-angiogenesis activities were mainly accompanied by a deactivation of the Wnt/beta-catenin pathway in HCT116 cells.
Document Type:Article
Volume:11
Issue:11
Page Number:2878-2884
ISSN No.:1742-206X
Translation or Not:no