Affiliation of Author(s):[1]Laboratory of Aging Research and Cancer Drug Target,State Key Laboratory of Biotherapy,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,China;[2]Personalized Drug Therapy Key Laboratory of Sichuan Province,Department of Pharmacy,Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,610072,China;[3]Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,610072,China
Journal:生物活性材料（英文）
Key Words:Biomaterial;Biotherapy;Drug delivery system;Vaccine development;Gene therapy;Stem cell therapy
Abstract:Biotherapy has recently become a hotspot research topic with encouraging prospects in various fields due to a wide range of treatments applications,as demonstrated in preclinical and clinical studies.However,the broad applications of biotherapy have been limited by critical challenges,including the lack of safe and efficient de-livery systems and serious side effects.Due to the unique potentials of biomaterials,such as good biocompati-bility and bioactive properties,biomaterial-assisted biotherapy has been demonstrated to be an attractive strategy.The biomaterial-based delivery systems possess sufficient packaging capacity and versatile functions,enabling a sustained and localized release of drugs at the target sites.Furthermore,the biomaterials can provide a niche with specific extracellular conditions for the proliferation,differentiation,attachment,and migration of stem cells,leading to tissue regeneration.In this review,the state-of-the-art studies on the applications of bio-materials in biotherapy,including drug delivery,vaccine development,gene therapy,and stem cell therapy,have been summarized.The challenges and an outlook of biomaterial-assisted biotherapies have also been discussed.
Volume:7
Issue:11
Page Number:29-48
ISSN No.:2452-199X
Translation or Not:no
CN No.:10-1775/Q