Lulu Cai
+
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Personal Information
Gender:Female
E-Mail:
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Gender:Female
E-Mail:3f576bce2f9b26ea560371e96fc27ce0ca4797c1cd74fe3d9d9fa48ab04aed191dcc2bdecaf1a8cde9fa1a59caa7ef194a303b906cd21df70b7d839ff1c9640a5f3dbd0e6761f2b020bdd6c46d471e80a9f2073860ca00fad2f4937d00e6d6fb24b7dee4e4dc9438e6bd1b669d93f82c4b6d9858020b214a72c83429440af8df
Affiliation of Author(s):[1]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy......
Journal:Journal of Controlled Release
Key Words:Gambogic acid; Calcium overload; Osteosarcoma; Tumor metastasis; Targeted therapy
Abstract:Calcium (Ca2+) overload therapy gained signiffcant attention in oncology. However, its therapeutic efffcacy remained limited due to insufffcient Ca2+ accumulation at the tumor site and suboptimal intracellular Ca2+ inffux. In this study, gambogic acid (GA), a natural phenolic compound known to promote Ca2+ inffux, was encapsulated within an enzyme-triggered, pH-responsive hydrogel (GM@Lip@CHP-Gel) containing Ca2+
hydrogen phosphate nanowires (CHP) to achieve a synergistic approach for bone tumor therapy. GM@Lip@CHPGel selectively responded to the slightly acidic tumor microenvironment...
Volume:377
Page Number:563-577
ISSN No.:0168-3659
Translation or Not:no
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