Lulu Cai
+
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Personal Information
Gender:Female
E-Mail:
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Gender:Female
E-Mail:3f576bce2f9b26ea560371e96fc27ce0ca4797c1cd74fe3d9d9fa48ab04aed191dcc2bdecaf1a8cde9fa1a59caa7ef194a303b906cd21df70b7d839ff1c9640a5f3dbd0e6761f2b020bdd6c46d471e80a9f2073860ca00fad2f4937d00e6d6fb24b7dee4e4dc9438e6bd1b669d93f82c4b6d9858020b214a72c83429440af8df
Affiliation of Author(s):[1]Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan ...
Journal:Journal of Molecular Structure
Key Words:Aggregation-induced emission; Melanoma; Tumor hypoxia microenvironment; Type I photosensitizer
Abstract:Melanoma, a highly aggressive tumor, presents substantial therapeutic challenges. Although imaging-guided photodynamic therapy (PDT) has emerged as a promising treatment approach, conventional photosensitizers (PSs) suffer from aggregation-caused quenching (ACQ) and hypoxia-induced therapeutic resistance. Aggregationinduced emission (AIE) PSs can overcome ACQ. However, their intrinsic hydrophobicity signiffcantly restricts biological applicability and causes uncontrolled aggregation. Therefore, OTTID, a water-soluble D-π-A type I AIE PS, was developed through structural modiffcation and...
Volume:1348
Page Number:143524
ISSN No.:0022-2860
Translation or Not:no
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