Lulu Cai
+
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Personal Information
Gender:Female
E-Mail:
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Gender:Female
E-Mail:3f576bce2f9b26ea560371e96fc27ce0ca4797c1cd74fe3d9d9fa48ab04aed191dcc2bdecaf1a8cde9fa1a59caa7ef194a303b906cd21df70b7d839ff1c9640a5f3dbd0e6761f2b020bdd6c46d471e80a9f2073860ca00fad2f4937d00e6d6fb24b7dee4e4dc9438e6bd1b669d93f82c4b6d9858020b214a72c83429440af8df
Affiliation of Author(s):Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province...
Journal:ACS NANO
Key Words:Spinal cordinjury,Core-shellmicroneedle,Pathology-guideddelivery,ExosomalmiRNA...
Abstract:Secondary injury following spinal cord injury (SCI) is not a unidimensional pathological process; rather, it involves a spatiotemporally organized cascade that rapidly evolves from an acute inflammatory storm and tissue breakdown to stalled repair and impaired regeneration in the subacute phase. However, most current therapeutic strategies depend on single-dose administration or isolated targets and thus fail to keep pace with the dynamic progression of SCI. Here, we developed a core–shell microneedle platform that aligns drug delivery with SCI progression by temporally decoupling the ....
ISSN No.:1936-086X
Translation or Not:no
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