个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
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论文成果
Research progress on antitumor mechanisms and combination therapies of gambogic acid
发布时间：2025-05-23 点击次数：
所属单位：[1]四川省医学科学院·四川省人民医院药学部,四川成都610072;[2]电子科技大学医学院,个体化药物治疗四川省重点实验室,四川成都610072;[3]西南交通大学生命科学与工程学院,四川成都610031;[4]西南医科大学药学院,四川泸州646000
发表刊物：Chinese Traditional and Herbal Drugs
关键字：gambogic acid;antitumor;apoptosis;migration;combined medication
摘要：Malignant tumors are a common global problem,which bring an overloaded economic burden to countries around the world.Gambogic acid is a caged xanthone bioactive component derived from Tenghuang(Garcinia hanburyi),which endows various pharmacological activities such as anti-inflammatory,retinopathy improvement,organ protection and so on.In recent years,a large number of investigations have confirmed that gambogic acid can be applied as an antitumor compound with great potential in the treatment of liver cancer,lung cancer,breast cancer,colorectal cancer and others,its mechanism involves in inhibiting cell proliferation,impeding migration and invasion,inducing apoptosis and autophagy,inhibiting angiogenesis,inducing ferroptosis and pyroptosis,targeting tumor inflammatory microenvironment,immune regulation and so on.Additionally,numerous researches have reported that gambogic acid also can be utilized in combination with various chemotherapy agents or natural products for the synergistic treatment of cancers.Therefore,this paper focuses on summarizing the antitumor mechanism of gambogic acid and its research progress in synergistic antitumor effects with other agents,providing a reference for the antitumor research of gambogic acid.
卷号：55
期号：7
页面范围：2423-2432
ISSN号：0253-2670
是否译文：否
CN号：12-1108/R
