个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
Integrated <i>in silico</i> and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway
发布时间：2025-05-23 点击次数：
所属单位：[1]Hosp Univ Elect Sci & Technol China, Dept Pharm, Chengdu 610072, Peoples R China;[2]Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R China;[3]Sichuan Univ, Sch Life Sci, Chengdu 610041, Peoples R China;[4]Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China;[5]Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
发表刊物：MOLECULAR BIOSYSTEMS
摘要：Arctigenin (ARG) has been previously reported to exert diverse biological activities including anti-proliferation, anti-inflammatory, and antiviral, etc. In the current study, the anti-metastasis and anti-angiogenesis activities of ARG were investigated. To further understand how ARG played these bioactivities, proteomic approaches were used to profile the proteome changes in response to ARG treatment using 2DE-MS/MS. Using these approaches, a total of 50 differentially expressed proteins were identified and clustered. Bioinformatics analysis suggested that multiple signalling pathways were involved. Moreover, ARG induced anti-metastatic and anti-angiogenesis activities were mainly accompanied by a deactivation of the Wnt/beta-catenin pathway in HCT116 cells.
文献类型：Article
卷号：11
期号：11
页面范围：2878-2884
ISSN号：1742-206X
是否译文：否
