个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
Biomaterial-assisted biotherapy:A brief review of biomaterials used in drug delivery,vaccine development,gene therapy,and stem cell therapy
发布时间：2025-05-23 点击次数：
所属单位：[1]Laboratory of Aging Research and Cancer Drug Target,State Key Laboratory of Biotherapy,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,China;[2]Personalized Drug Therapy Key Laboratory of Sichuan Province,Department of Pharmacy,Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,610072,China;[3]Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,610072,China
发表刊物：生物活性材料（英文）
关键字：Biomaterial;Biotherapy;Drug delivery system;Vaccine development;Gene therapy;Stem cell therapy
摘要：Biotherapy has recently become a hotspot research topic with encouraging prospects in various fields due to a wide range of treatments applications,as demonstrated in preclinical and clinical studies.However,the broad applications of biotherapy have been limited by critical challenges,including the lack of safe and efficient de-livery systems and serious side effects.Due to the unique potentials of biomaterials,such as good biocompati-bility and bioactive properties,biomaterial-assisted biotherapy has been demonstrated to be an attractive strategy.The biomaterial-based delivery systems possess sufficient packaging capacity and versatile functions,enabling a sustained and localized release of drugs at the target sites.Furthermore,the biomaterials can provide a niche with specific extracellular conditions for the proliferation,differentiation,attachment,and migration of stem cells,leading to tissue regeneration.In this review,the state-of-the-art studies on the applications of bio-materials in biotherapy,including drug delivery,vaccine development,gene therapy,and stem cell therapy,have been summarized.The challenges and an outlook of biomaterial-assisted biotherapies have also been discussed.
卷号：7
期号：11
页面范围：29-48
ISSN号：2452-199X
是否译文：否
CN号：10-1775/Q
