个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment
发布时间：2025-05-23 点击次数：
所属单位：[1]Department of Pharmacy,Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China;[2]Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China;[3]Health Management Center,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China;[4]Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026),Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,Chengdu 610072,China;[5]Department of Pharmacy,Jianyang People’s Hospital of Sichuan Province,Jianyang 641400,China
发表刊物：亚洲药物制剂科学（英文）
关键字：Small interfering RNA;Tumor microenvironment;siRNA delivery;Cancer therapy;Co-delivery
摘要：How to effectively transform the pro-oncogenic tumor microenvironments(TME)surrounding a tumor into an anti-tumoral never fails to attract people to study.Small interfering RNA(siRNA)is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference(RNAi).The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent years.Using siRNA drugs to silence critical proteins in TME was one of the most efficient solutions.However,the manufacture of a siRNA delivery system faces three major obstacles,i.e.,appropriate cargo protection,accurately targeted delivery,and site-specific cargo release.In the following review,we summarized the pharmacological actions of siRNA drugs in remolding TME.In addition,the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly discussed.In the meanwhile,the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also presented.Ultimately,we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene therapy.This summary offers a thorough analysis and roadmap for general readers working in the field.
卷号：18
期号：5
页面范围：51-76
ISSN号：1818-0876
是否译文：否
CN号：21-1608/R
