个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
Blood compatible heteratom-doped carbon dots for bio-imaging of human umbilical vein endothelial cells
发布时间：2025-05-23 点击次数：
所属单位：[1]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Personalized Drug Therapy Key Lab Sichuan Prov, Sch Med,Dept Pharm, Chengdu 610072, Peoples R China;[2]China Univ Petr, Coll New Energy & Mat, Beijing Key Lab Biogas Upgrading Utilizat, State Key Lab Heavy Oil Proc, Beijing 102249, Peoples R China;[3]Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc, Chengdu 610041, Peoples R China;[4]Collaborat Innovat Ctr, Chengdu 610041, Peoples R China
发表刊物：CHINESE CHEMICAL LETTERS
关键字：Carbon dots; Fluorescent; Cell imaging; Erythrocyte; Blood compatibility
摘要：Carbon dots have unique advantages in biological applications owing to their excellent optical properties. However, the biosafety evaluation of carbon dots has limitations owing to cytotoxicity in vitro, and there is little pre-safety evaluation before in vivo and clinical applications. Whether the carbon dots are or not suitable for applications in vivo, evaluation analysis can be made based on hemolysis and changes in erythrocyte morphology. In this work, a green fluorescent N, S-doped carbon dots (N, S-CDs) were obtained by hydrothermal method, tobias acid, and m-phenylenediamine as precursors. N, S-CDs not only possessed excellent dispersibility, uniform particle size, high quantum yield (37.2%) and stable photoluminescence property but also retain their photostability and strong fluorescence intensity in the acid/alkaline solutions, different ionic strengths (NaCl) and under 365 nm UV illumination. Moreover, the N, S-CDs displayed low cytotoxicity and high cellular uptake efficiency in human umbilical vein endothelial cells (HUVEC) and excellent blood compatibility to the erythrocyte. It is foreseeable that N, S-CDs could be further studied as a promising biological imaging agent in vivo. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
文献类型：Article
卷号：31
期号：3
页面范围：769-773
ISSN号：1001-8417
是否译文：否
