个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
Tumor microenvironment-responsive hyaluronate-calcium carbonate hybrid nanoparticle enables effective chemotherapy for primary and advanced osteosarcomas
发布时间：2025-05-23 点击次数：
所属单位：[1]Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China;[2]China Med Univ, Affiliated Hosp 4, Dept Orthoped, Shenyang 110032, Liaoning, Peoples R China;[3]Sichuan Prov Peoples Hosp, Hosp Univ Elect Sci & Technol China, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Sichuan, Peoples R China;[4]Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA;[5]Sun Yat Sen Univ, Affiliated Hosp 3, Guangdong Prov Key Lab Liver Dis, Guangzhou 510630, Guangdong, Peoples R China
发表刊物：NANO RESEARCH
关键字：hybrid nanomedicine; tumor-acidity responsiveness; controlled drug delivery; multi-stage osteosarcoma; chemotherapy
摘要：Osteosarcoma is the most common malignancy in the bone. Current chemotherapy offers limited efficacy with significant side effects, especially for advanced and relapsed osteosarcomas. Nanoparticle-formulated chemotherapeutic drugs may be used to resolve these issues, but several aspects of these formulations remain unsatisfactory, such as how to improve their stability in the bloodstream, prevent undesirable drug leakage, and enhance targeted drug accumulation in the tumor. In this study, a tumor microenvironment-responsive calcium carbonate (CaCO3)-crosslinked hyaluronate (HA) nanoparticle was prepared via a "green" process to effectively deliver doxorubicin (DOX) for the treatment of various stages of osteosarcoma. The DOX-loaded hyaluronate-calcium carbonate hybrid nanoparticle (HA-DOX/CaCO3) demonstrated superior stability both in vitro and in vivo, and rapidly released DOX at the tumor site when triggered by the acidic tumor microenvironment. Compared with free DOX and a non-crosslinked nanoparticle (HA-DOX), HA-DOX/CaCO3 exhibited the most potent inhibition efficacy toward both primary and advanced models of murine osteosarcoma, resulting in effective tumor inhibition, improved survival time, and reduced adverse effects. Most importantly, in the advanced osteosarcoma model, HA-DOX/CaCO3 potently suppressed tumor growth by 84.6%, which indicates the potential of this platform for osteosarcoma treatment, particularly for advanced and relapsed cases. The proposed polysaccharide nanoparticle would be a promising drug delivery platform to advance osteosarcoma nanomedicine.
文献类型：Article
卷号：11
期号：9
页面范围：4806-4822
ISSN号：1998-0124
是否译文：否
CN号：11-5974/O4
