个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
pH-responsive hydrogel with gambogic acid and calcium nanowires for promoting mitochondrial apoptosis in osteosarcoma
发布时间：2026-06-02 点击次数：
所属单位：[1]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy......
发表刊物：Journal of Controlled Release
关键字：Gambogic acid; Calcium overload; Osteosarcoma; Tumor metastasis; Targeted therapy
摘要：Calcium (Ca2+) overload therapy gained signiffcant attention in oncology. However, its therapeutic efffcacy remained limited due to insufffcient Ca2+ accumulation at the tumor site and suboptimal intracellular Ca2+ inffux. In this study, gambogic acid (GA), a natural phenolic compound known to promote Ca2+ inffux, was encapsulated within an enzyme-triggered, pH-responsive hydrogel (GM@Lip@CHP-Gel) containing Ca2+
hydrogen phosphate nanowires (CHP) to achieve a synergistic approach for bone tumor therapy. GM@Lip@CHPGel selectively responded to the slightly acidic tumor microenvironment...
卷号：377
页面范围：563-577
ISSN号：0168-3659
是否译文：否
