个人信息

  • 教师姓名：蔡璐璐

  • 教师英文名称：Lulu Cai

  • 教师拼音名称：Cai Lulu

  • 电子邮箱：cailulu@med.uestc.edu.cn

  • 学历：博士研究生毕业

  • 性别：女

  • 联系方式：cailulu@med.uestc.edu.cn

  • 学位：工学博士学位

  • 职称：教授

  • 博士生导师

  • 曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。

  • 所属院系： 医学院

  • 学科：生物医学工程
    药剂学

其他联系方式

  • 通讯/办公地址：

  • 邮箱：

论文成果

A water-soluble type I photosensitizer with near-infrared aggregation-induced emission for enhanced hypoxic melanoma photodynamic therapy

发布时间：2026-06-02  点击次数：

所属单位：[1]Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan ...

发表刊物：Journal of Molecular Structure

关键字：Aggregation-induced emission; Melanoma; Tumor hypoxia microenvironment; Type I photosensitizer

摘要：Melanoma, a highly aggressive tumor, presents substantial therapeutic challenges. Although imaging-guided photodynamic therapy (PDT) has emerged as a promising treatment approach, conventional photosensitizers (PSs) suffer from aggregation-caused quenching (ACQ) and hypoxia-induced therapeutic resistance. Aggregationinduced emission (AIE) PSs can overcome ACQ. However, their intrinsic hydrophobicity signiffcantly restricts biological applicability and causes uncontrolled aggregation. Therefore, OTTID, a water-soluble D-π-A type I AIE PS, was developed through structural modiffcation and...

卷号：1348

页面范围：143524

ISSN号：0022-2860

是否译文：否

上一条：Exploring the Potential of an End-to-End AI Design Framework for Photoresponsive Drug Delivery

下一条：Sustainable poly(thioctic acid)-based elastomer for super-stretchable electronic sensors

    清水河校区：成都市高新区（西区）西源大道2006号　邮编： 611731  
    沙河校区：成都市建设北路二段四号　邮编：610054
    蜀ICP备 05006379 号   I　川公网安备 51019002000280 号