个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
Berberine suppresses colorectal cancer progression by inducing ferroptosis-mediated energy metabolism disorders
发布时间：2026-06-02 点击次数：
所属单位：[1]Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Department of ...
发表刊物：Journal of Advanced Research
关键字：Berberine; Colorectal cancer; Ferroptosis; Gli1/STAT3-FNR axis; Mitochondrial energy metabolism
摘要：Introduction: Berberine (BBR), the predominant isoquinoline alkaloid in Coptidis Rhizoma, exhibits remarkable anti- colorectal cancer (CRC) activity. However, whether BBR triggers CRC cell death through ferroptosis-associated disruption of energy metabolism remains to be elucidated.
Objective: To investigate if BBR induces mitochondrial energy metabolism disorder in CRC cells by regulating the ferroptosis signaling pathway.
Methods: BBR’s effects on malignant phenotypes were evaluated in vitro (human cell line HCT116, murine cell line CT26 cells at 10, 20, 40 lM) and in vivo (80 mg/kg) ...
ISSN号：2090-1224
是否译文：否
