个人信息
教师姓名:蔡璐璐
教师英文名称:Lulu Cai
教师拼音名称:Cai Lulu
电子邮箱:cailulu@med.uestc.edu.cn
学历:博士研究生毕业
性别:女
联系方式:cailulu@med.uestc.edu.cn
学位:工学博士学位
职称:教授
博士生导师
曾获荣誉:国家高层次青年人才,四川省青年五四奖章,四川省杰出青年基金,四川省医学科技奖一等奖,四川省学术技术带头人后备人,四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员,Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志(青年)编委。
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所属院系: 医学院
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学科:生物医学工程
药剂学
其他联系方式
通讯/办公地址:
邮箱:
论文成果
Targeted co-delivery of curcumin and astragaloside IV via hybrid membrane-coated biomimetic liposomes for enhanced lung cancer therapy
发布时间:2026-06-02 点击次数:
所属单位:[1]Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan...
发表刊物:International Journal of Nanomedicine
关键字:lung cancer; curcumin; astragaloside IV; biomimetic liposomes; targeted delivery
摘要:Background: Lung cancer is the malignant tumor with the highest incidence and lethality worldwide. Existing therapeutic modalities suffer from side effects, drug resistance, and limited efficacy… Curcumin (Cur) and astragaloside IV (AS) are promising natural anti-cancer agents; however, poor aqueous solubility and low bioavailability limit clinical efficacy. Methods/Results: Optimal synergistic ratio determined; CM@AC liposomes 111.86±4.12 nm, ζ≈−20.8 mV, EE Cur 63.81%, AS 60.38%; superior tumor targeting, immune evasion, enhanced cytotoxicity/apoptosis/invasion inhibition; in vivo tumor ...
卷号:21
页面范围:558285
ISSN号:1176-9114
是否译文:否

