Laboratory for Optical Imaging in Biology/生物光学成像实验室

我们是一个高度交叉融合的实验室，致力于研究新的光学显微成像技术，为生命科学领域、特别是分子和细胞生物学领域的重要问题提供观测、度量和解析的新工具。我们追求新的成像技术具有更优异的空间分辨率、更快的成像速度、更高的探测灵敏度、更多的信息维度以及能够定量观测复杂生命活动的能力。为此，我们采用的技术包括单分子探测、超分辨显微成像、荧光光谱成像、活细胞多色动态成像、无标记非线性光学成像等在内的诸多前沿光学成像方法，同时结合了先进的光源系统（脉冲激光器、光学频率梳）、光学调制技术、信号探测技术和数据分析方法。我们还利用了前沿生物化学手段对分子和细胞进行标记、改造和操纵，从多个维度帮助我们揭开生命的内在奥秘。  

Our lab is an interdisciplinary hub dedicated to pioneering new optical microscopy techniques that address key challenges in life sciences, with a focus on molecular and cellular biology. We strive to develop imaging tools that offer exceptional spatial resolution, faster acquisition speeds, heightened detection sensitivity, richer data dimensions, and the capability to quantitatively observe complex biological processes. Our approach integrates a variety of cutting-edge technologies, including single-molecule detection, super-resolution microscopy, fluorescence spectral imaging, live-cell multicolor imaging, and label-free nonlinear optical imaging. These advanced imaging methods are powered by state-of-the-art light sources—such as pulsed lasers and optical frequency combs—along with optical modulation, signal detection, and advanced data analysis techniques. In addition, we employ leading biochemical strategies to label, modify, and manipulate molecules and cells, enabling us to unravel the deeper mysteries of life from multiple dimensions.

More details about our Research: Click here

More details about our Publications: Click here

News: Unmix excitation spectral data without any measured reference spectra: Excitation spectral microscopy for highly multiplexed intracellular imaging via quasi-blind unmixing  (2024). [available here] 

News: A new approach for fast and quantitative spectral microscopy: Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing  (2021). [available here]