段旭君
Professional Title:Professor
Supervisor of Doctorate Candidates
Biography:
Dr. Xujun Duan is a professor of Biomedical Engineering at the University of Electronic Science and Technology of China, Chengdu, China. She received her PhD in Biomedical Engineering at the University of Electronic Science and Technology of China under the supervision of Dr. Huafu Chen, and conducted a Joint PhD study at Stanford University under the supervision of Dr. Vinod Menon. Her long-term research goal is to address how brain anatomy, function and connectivity are altered in autism spectrum, and how they vary across the population, by using multi-modal brain imaging techniques and computational methods.
Over the past decade, she has dedicated to delineate a comprehensive and consistent mapping of the different structure and function of the autistic brain, and reaches a consensus that the “social brain” are the most affected regions in the autistic brain at different levels and modalities. She further proposed a personalized functional-connectivity guided brain stimulation strategy targeting the “social brain” to improve social deficits of severe autism. She is the PI of 5 research projects funded by the National Natural Science Foundation of China, and awarded the first prize of the Science and Technology Progress Awards of Sichuan Province, China. She was one of the Keynote speakers of the 2023 Annual Meeting of the Organization for Human Brain Mapping (OHBM).
Her findings have been published in influential journals including PNAS, Biological Psychiatry, Schizophrenia Bulletin, Cerebral Cortex and Human Brain Mapping.
Ongoing and recently completed projects/fundings:
1. National Natural Science Foundation of China, 82322035, Brain Imaging of Autism, 2024/01-2027/12, PI
2. National Natural Science Foundation of China,62273076,Multi-source fusion-based neural mechanism modeling of Autism spectrum disorder and auxiliary diagnosis and treatment algorithms,2023/01-2026/12,PI
3. National Natural Science Foundation of China,81871432,Neural mechanism of transcranial magnetic stimulation therapy for autism: A multimodal MRI study,2019/01-2022/12, PI
4. National Natural Science Foundation of China,61673089,Brain plasticity of autism in response to early behavioral intervention: A multimodal MRI study,2017/01-2020/12, PI
Selected Publications:
2024
[1] Xiaolong Shan, · Peng Wang, · Qing Yin,· Youyi Li, · Xiaotian Wang, · Yu Feng,· Jinming Xiao, · Lei Li, ·Xinyue Huang, · Huafu Chen, · Xujun Duan, Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles, European Child & Adolescent Psychiatry, 2024, Accepted
[2] Xinyue Huang, Leying Gao, Jiming Xiao, Lei Li, Xiaolong Shan, Huafu Chen, Xiaoqian Chai*, Xujun Duan*, Family environment modulates linkage of transdiagnostic psychiatric phenotypes and dissociable brain features in the developing brain, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2024, Accepted
[3] 单晓龙,陈华富,段旭君*,孤独症谱系障碍多模态磁共振脑影像模式识别。心理科学进展,2024,vol. 32, No. 7
[4] Zhao W, Li L, Yang X, Wang X, Kou J, Chen J, Chen H, Wang Q, Duan X. Brain development of a school-aged boy with autism spectrum condition talented in arithmetic: a case report. Psychoradiology. 2024 Apr 18;4:kkae008. doi: 10.1093/psyrad/kkae008.
2023
[5] Xinyue Huang, Yating Ming, Weixing Zhao, Rui Feng, Yuanyue Zhou, Lijie Wu, Jia Wang, Jinming Xiao, Lei Li, Xiaolong Shan, Jing Cao, Xiaodong Kang, Huafu Chen*, Xujun Duan*. Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain, Molecular Autism, 2023,14:41.
[6] Xiaolong Shan, Lucina Q. Uddin, Rui Ma, Pengfei Xu, Jinming Xiao, Lei Li, Xinyue Huang, Yu Feng, Changchun He, Huafu Chen*, Xujun Duan*. Disentangling the individual-shared and individual-specific subspace of altered brain functional connectivity in autism spectrum disorder, Biological Psychiatry. DOI: 10.1016/j.biopsych.2023.09.012
[7] 郑清予,李镭,肖金明,陈华富,段旭君。孤独症谱系障碍默认网络与任务正激活网络交互的共激活模式研究,《中华精神科杂志》,2023,56 (4) 56 (4): 284-291,DOI: 10.3760/cma.j.cn113661-20221009-00278 (北大核心)
2022
[1] Xujun Duan*, Huafu Chen. Mapping brain functional and structural abnormities in autism spectrum disorder: moving towards precision treatment. Psychoradiology, 2022, 2,78-85.
[2] JinmingXiao, Lucina Q.Uddin, YaoMeng, LeiLi, LeyingGao, XiaolongShan, XinyueHuang, WeiLiao, HuafuChen*, XujunDuan*. A spatio-temporal decomposition framework for dynamic functional connectivity in the human brain. NeuroImage, 2022, 263:119618
[3] Lei Li, Xinyue Huang, Jinming Xiao, Qingyu Zheng, Xiaolong Shan, Changchun He, Wei Liao, Huafu Chen*, Vinod Menon*, Xujun Duan*. Neural synchronization predicts marital satisfaction. Proc. Natl. Acad. Sci. U.S.A., 2022, 119 (34), e2202515119.
[4] Lei Li#, Xiaoran Su#, Qingyu Zheng, Jinming Xiao, XinYue Huang, Wan Chen, Kaihua Yang, Lei Nie, Xin Yang, Huafu Chen*, Shengli Shi*, Xujun Duan*. Cofluctuation analysis reveals aberrant default mode network patterns in adolescents and youths with autism spectrum disorder. Human Brain Mapping, 2022, 43(15):4722-4732.
[5] Xiaolong Shan, Lucina Q. Uddin, Jinming Xiao, Changchun He, Zihan Ling, Lei Li, Xinyue Huang, Huafu Chen, Xujun Duan*. Mapping the heterogeneous brain structural phenotype of autsim spectrum disorder using the normative model. Biological Psychiatry. June 1, 2022, 91:967–976.
2021
[6] Xinyue Huang, Lei Li, Zihan Ling, Leying Gao, Huafu Chen, Xujun Duan*. Gut microbiome diversity mediates the association between right dorsolateral prefrontal cortex and anxiety level. Brain Image and Behavior, 2022 Feb;16(1):397-405.
[7] Heng Chen#, Fengmei Lu#, Xiaonan Guo, Yajing Pang, Changchun He, Shaoqiang Han, Xujun Duan*, Huafu Chen*. Dimensional Analysis of Atypical Functional Connectivity of Major Depression Disorder and Bipolar Disorder. Cerebral Cortex, 2022 Mar 4;32(6):1307-1317.
[8] Changchun He, Jesus M. Cortes, Xiaodong Kang, Jing Cao, Heng Chen, Xiaonan Guo, Ruishi Wang, Lingyin Kong, Xinyue Huang, Jinming Xiao, Xiaolong shan, Rui Feng, Huafu Chen, Xujun Duan*. Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder. Human Brain Mapping, 2021, 42(10):3282-3294.
[9] Jinming Xiao, Huafu Chen*, Xiaolong Shan, Changchun He, Ya Li, Xiaonan Guo, Heng Chen, Wei Liao, Lucina Q. Uddin*, Xujun Duan*. Linked social–communication dimensions and connectivity in functional brain networks in autism spectrum disorder. Cerebral Cortex, 2021, 31(8):3899-3910. DOI: 10.1093/cercor/bhab057
[10] Xiaonan Guo, Xujun Duan*,John Suckling, JiaWang, Xiaodong Kang, Heng Chen, Bharat B. Biswal, Jing Cao, Changchun He, Jinming Xiao, Xinyue Huang, Runshi Wang, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Jingping Zhao, Lijie Wu* and Huafu Chen*, Mapping progressive gray matter alterations in early childhood autistic brain. Cerebral Cortex, 2021,31(3):1500-1510.
[11] Xujun Duan#, Changchun He#, Jianjun Ou, Runshi Wang, Jinming Xiao, Lei Li, Renrong Wu, Yan Zhang*, Jingping Zhao*, Huafu Chen*. Reduced hippocampal volume and its relationship with verbal memory and negative symptoms in treatment-naive first-episode adolescent-onset schizophrenia. Schizophrenia Bulletin, 2021, 47(1): 64-74.
2020
[12] Lei Li, Changchun He, Taorong Jian, Xiaonan Guo, Jinming Xiao, Ya Li, Heng Chen, Xiaodong Kang, Huafu Chen, Xujun Duan*. Attenuated link between the medial prefrontal cortex and the amygdala in children with autism spectrum disorder: evidence from effective connectivity within the “social brain”. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 111:110147. doi: 10.1016/j.pnpbp.2020.110147
[13] Xujun Duan#, Maolin Hu#, Xinyue Huang, Chan Su, Xiaofen Zong, Xia Dong, Changchun He, Jinming Xiao, Haoru Li, Jinsong Tang*, Xiaogang Chen*, Huafu Chen*. Effect of risperidone monotherapy on dynamic functional connectivity of insular subdivisions in treatment-naive, first-episode schizophrenia. Schizophrenia Bulletin, 2020, 46(3): 650-660.
[14] Changchun He, Huafu Chen*, Lucina Q. Uddin, Asier Erramuzpe, Paolo Bonifazi, Xiaonan Guo, Jinming Xiao, Heng Chen, Xinyue Huang, Lei Li, Wei Sheng, Wei Liao, Jesus M. Cortes*, Xujun Duan*. Structure-Function Connectomics Reveals Aberrant Developmental Trajectory Occurring at Pre-adolescence in the Autistic Brain. Cerebral Cortex, 2020, 30(9):5028-5037.
[15] Xiaonan Guo, Xujun Duan*, Heng Chen, Changchun He, Jinming Xiao, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Huafu Chen*. Altered inter- and intrahemispheric functional connectivity dynamics in autistic children. Human Brain Mapping, 2020, 41 (2), 419-428
[16] Xujun Duan, Runshi Wang, Jinming Xiao, Ya Li, Xinyue Huang, Xiaonan Guo, Jing Cao, Liyao He, Changchun He, Zihan Ling, Xiaolong Shan, Heng Chen, Xiaodong Kang*, Huafu Chen*. Subcortical structural covariance in young children with autism spectrum disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 99:109874. DOI: 10.1016/j.pnpbp.2020.109874
[17] Xujun Duan#, Maolin Hu#, Xinyue Huang, Xia Dong, Xiaofen Zong, Changchun He, Jinming Xiao, Jinsong Tang*, Xiaogang Chen*, Huafu Chen*. Effects of risperidone monotherapy on the default-mode network in antipsychotic-naïve first-episode schizophrenia: Posteromedial cortex heterogeneity and relationship with the symptom improvements. Schizophrenia Research, 2020, 218:201-208. DOI: 10.1016/j.schres.2020.01.001
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