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- 出生日期：1983-09-02
- 电子邮箱：zhaowang92@uestc.edu.cn
- 入职时间：2018-06-01
- 学历：博士研究生毕业
- 办公地点：清水河科研楼4号C区336房间
- 性别：男
- 学位：哲学博士学位
- 职称：教授
- 博士生导师
- 曾获荣誉：国家青年特聘专家，荣获四川省“天府峨眉计划”、成都市“四派人才”、“蓉漂计划”称号
- 学科：电子科学与技术
物理电子学
Coronary artery calcification and plaque stability: an optical coherence tomography study
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- 所属单位：[1]Harbin Med Univ, Dept Cardiol, Affiliated Hosp 2, 246 Xuefu Rd, Harbin 150086, Peoples R China;[2]Minist Educ, Key Lab Myocardial Ischemia, Harbin, Peoples R China;[3]Univ Elect & Sci Technol China, Sch Elect Sci & Engn, 2006 Xiyuan Ave, Chengdu 611731, Peoples R China
- 发表刊物：HELIYON
- 关键字：Coronary artery calcification; Optical coherence tomography; Acute coronary syndrome
- 摘要：Background: Coronary artery calcification (CAC), a surrogate of atherosclerosis, is related to stent underexpansion and adverse cardiac events. However, the effect of CAC on plaque stability is still controversial and the morphological significance of CAC has yet to be elucidated.Methods: A retrospective series of 419 patients with acute coronary syndrome (ACS) who underwent optical coherence tomography (OCT) were enrolled. Patients were classified into three groups based on the calcification size in culprit plaques and the features of the culprit and non culprit plaques among these groups were compared. Logistic regression was used to analyze independent risk factors for culprit plaque rupture and the nonlinear relationship between calcification parameters and culprit plaque rupture. Furthermore, we compared the detailed calcification parameters of different kinds of plaques.Results: A total of 419 culprit plaques and 364 non-culprit plaques were identified. The incidence of calcification was 53.9 % in culprit plaques and 50.3 % in non-culprit plaques. Compared with culprit plaques without calcification, plaque rupture, macrophages and cholesterol crystals were more frequently observed in the spotty calcification group, and the lipid length was longer; the incidence of macrophages and cholesterol crystals was higher in the macrocalcification group. Calcification tended to be smaller in ruptured plaques than in non-ruptured plaques. Moreover, the arc and length of calcification were greater in culprit plaques than in non-culprit plaques.Conclusions: Vulnerable features were more frequently observed in culprit plaques with spotty calcification, whereas the presence of macrocalcification calcifications did not significantly increase plaque vulnerability. Calcification tends to be larger in culprit plaques than in non-culprit plaques.
- 文献类型：Article
- 卷号：9
- 期号：12
- ISSN号：24058440
- 是否译文：否