Lulu Cai

Doctor of Engineering

With Certificate of Graduation for Doctorate Study

Recommended Ph.D.Supervisor

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CDDS Lab > Scientific Research > Paper Publications

Multichannel Immune Nanoregulators Suppress Lactic Acid Metabolism and Lactic Acid-Shaped Acidic Microenvironment to Uproot Anti-Tumor Immunosuppression

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Affiliation of Author(s):[1]Department of Orthopedics and Central Laboratory, Sichuan Academy of Medical Sciences...
Journal:Advanced Materials
Key Words:acidic tumor microenvironment attenuation; anaerobic glycolysis regulation...
Abstract:Lactic acid (LA) itself and the LA-shaped acidic tumor microenvironment (TME) are identified as root causes of cancer immunosuppression, and no effective strategies address them. Here a multichannel immune nanoregulator is engineered
 to dampen acidic TME and repolarize non-inflammatory macrophages to uproot this source of cancer immunosuppression, wherein fluorocarbon chains (FC)-modified mesoporous silica (FM) serves as nanoreactors and carriers to in situ synthesize CaO2 and load R848, respectively, followed by liposome coating, anti-CD105 modification and FC-mediated O2 binding in sequence...
Volume:38
Issue:3
Page Number:e12230
ISSN No.:0935-9648​ / 1521-4095
Translation or Not:no

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