Lulu Cai
+
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Personal Information
Gender:Female
E-Mail:
Doctor of Engineering
With Certificate of Graduation for Doctorate Study
Gender:Female
E-Mail:3f576bce2f9b26ea560371e96fc27ce0ca4797c1cd74fe3d9d9fa48ab04aed191dcc2bdecaf1a8cde9fa1a59caa7ef194a303b906cd21df70b7d839ff1c9640a5f3dbd0e6761f2b020bdd6c46d471e80a9f2073860ca00fad2f4937d00e6d6fb24b7dee4e4dc9438e6bd1b669d93f82c4b6d9858020b214a72c83429440af8df
Affiliation of Author(s):[1]Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Department of ...
Journal:Journal of Advanced Research
Key Words:Berberine; Colorectal cancer; Ferroptosis; Gli1/STAT3-FNR axis; Mitochondrial energy metabolism
Abstract:Introduction: Berberine (BBR), the predominant isoquinoline alkaloid in Coptidis Rhizoma, exhibits remarkable anti- colorectal cancer (CRC) activity. However, whether BBR triggers CRC cell death through ferroptosis-associated disruption of energy metabolism remains to be elucidated.
Objective: To investigate if BBR induces mitochondrial energy metabolism disorder in CRC cells by regulating the ferroptosis signaling pathway.
Methods: BBR’s effects on malignant phenotypes were evaluated in vitro (human cell line HCT116, murine cell line CT26 cells at 10, 20, 40 lM) and in vivo (80 mg/kg) ...
ISSN No.:2090-1224
Translation or Not:no
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