个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
-
所属院系： 医学院
-
学科：生物医学工程
药剂学
其他联系方式
通讯/办公地址：
邮箱：
论文成果
Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment
发布时间：2025-05-23 点击次数：
所属单位：[1]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Pharm,Personalized Drug Therapy Key Lab Sichu, Chengdu 610072, Peoples R China;[2]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu 610072, Peoples R China;[3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Lab Med, Chengdu 610072, Peoples R China;[4]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Hlth Management Ctr, Chengdu 610072, Peoples R China;[5]Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Chinese Acad Med Sci 2019RU026, Res Unit Blindness Prevent, Chengdu 610072, Peoples R China;[6]Jianyang Peoples Hosp Sichuan Prov, Dept Pharm, Jianyang 641400, Peoples R China
发表刊物：ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：Small interfering RNA; Tumor microenvironment; siRNA delivery; Cancer therapy; Co-delivery
摘要：How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA (siRNA) is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference (RNAi). The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent years. Using siRNA drugs to silence critical proteins in TME was one of the most efficient solutions. However, the manufacture of a siRNA delivery system faces three major obstacles, i.e., appropriate cargo protection, accurately targeted delivery, and site-specific cargo release. In the following review, we summarized the pharmacological actions of siRNA drugs in remolding TME. In addition, the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly discussed. In the meanwhile, the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also presented. Ultimately, we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene therapy. This summary offers a thorough analysis and roadmap for general readers working in the field.(c) 2023 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
文献类型：Review
卷号：18
期号：5
ISSN号：1818-0876
是否译文：否
