个人信息
教师姓名：蔡璐璐
教师英文名称：Lulu Cai
教师拼音名称：Cai Lulu
电子邮箱：cailulu@med.uestc.edu.cn
学历：博士研究生毕业
性别：女
联系方式：cailulu@med.uestc.edu.cn
学位：工学博士学位
职称：教授
博士生导师
曾获荣誉：国家高层次青年人才，四川省青年五四奖章，四川省杰出青年基金，四川省医学科技奖一等奖，四川省学术技术带头人后备人，四川省高层次海外留学人才。中国抗癌协会纳米肿瘤学分会委员、中国医药生物技术协会纳米技术分会委员、四川省药学会纳米药物专委会副主任委员，Signal Transduct Target Ther和Asian J Pharm Sci等SCI杂志（青年）编委。
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所属院系： 医学院
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学科：生物医学工程
药剂学
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论文成果
Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs
发布时间：2025-05-23 点击次数：
所属单位：[1]Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90032 USA;[2]Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90032 USA;[3]Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Raleigh, NC 27599 USA;[4]North Carolina State Univ, Raleigh, NC 27695 USA;[5]Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA;[6]Univ Calif Los Angeles, Ctr Minimally Invas Therapeut, Los Angeles, CA 90032 USA;[7]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Pharm, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 611731, Sichuan, Peoples R China;[8]Nanjing Univ, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, MOE, Nanjing 210023, Jiangsu, Peoples R China;[9]Nanjing Univ, Sch Chem & Chem Engn, MOE, Key Lab High Performance Polymer Mat & Technol, Nanjing 210023, Jiangsu, Peoples R China;[10]Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA USA;[11]Univ Calif Los Angeles, Dept Radiol, Los Angeles, CA USA;[12]Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA
发表刊物：SCIENCE ADVANCES
关键字：Mammals - Glucose
摘要：Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction. Both high insulin loading efficiency (95%) and loading capacity (49%) can be achieved. In the presence of a hyperglycemic state, the glucose-responsive phenylboronic acid (PBA) binds glucose instantly and converts the charge of the polymeric moiety from positive to negative, thereby enabling the release of insulin from the complex. Adjusting the ratio of the positively charged group to PBA achieves inhibited insulin release from the complex under normoglycemic conditions and promoted release under hyperglycemic conditions. Through chemically induced type 1 diabetic mouse and swine models, in vivo hyperglycemia-triggered insulin release with fast response is demonstrated after the complex is administrated by either subcutaneous injection or transdermal microneedle array patch.
文献类型：Article
卷号：5
期号：7
ISSN号：2375-2548
是否译文：否
