迄今，已申请近40项国家发明专利（授权国家发明专利20余项，其中1项获上海市优秀发明一等奖），在Circulation、IEEE  J. Bio. Health Info., IEEE Sensors J., Frontiers in Immunology,  Frontiers in Pharmacology、Phys. Med. Biol.、IEEE Trans. Info. Tech.  Biomed.、 Int. J.  Bioelectromagnetism、《中国生物医学工程学报》、《生物医学工程学杂志》、《仪器仪表学报》等本领域权威学术期刊和IEEE  EMBC、SPIE等国际会议上发表学术论文60余篇（其中，SCI检索50余篇），受邀多次参加国际国内学术大会，并作大会主题报告或分会场邀请报告（PRML2020-2022成都，ICCBB2019,日本，ICBB2019厦门，AICAE2019武汉，2021、2020及2019中国心律学大会北京，2019中国生物医学工程年会济南）及多次担任国际学术大会TPC主席（PRML2020-2022成都）。近年以一作及通讯作者发表的主要期刊及国际会议论文如下：

2022年 Journal Papers期刊论文：

[1] H. Ullah, MBB. Heyat^*, F. Akhtar, Y. Lin^*,  D. Lai^*,  et. al, "An End-to-End Cardiac Arrhythmia Recognition Method with an Effective DenseNet Model on Imbalanced Datasets Using ECG Signal," Computational Intelligence and Neuroscience , vol. 2022, Article ID. 9475162, Sep. 2022. (JCR 3, IF 3.12)

[2] M Belal B. Heyat, F. Akhtar, S. J. Abbas, M. Al-Sarem^*, D. Lai^*, K. Wu^*,  et al, "Wearable Flexible Electronics Based Single Lead  Electrocardiogram Sensor for Psycho-Neurological Mental Stress Detection  System Using Machine Learning Models," Biosensors-Basel, vol. 12, Article ID. 427, 2022. (JCR 2, IF 5.519)

[3] FI. Khan, F. Hassan, D. Lai^*, "In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 Receptor," Frontiers in Immunology, vol 12, Article ID 794780, Jan, 2022. (JCR 2, IF 7.561)

[4] FI. Khan, Lobb K, D. Lai^*, "The Molecular Basis of the Effect of Temperature on the Structure and function of SARS-CoV-2 Spike Protein," Frontiers in Molecular Biosciences, Mar. 2022, vol. 9, Article ID 794960, Mar. 2022. (JCR 2, IF 5.246)

[5] FI. Khan, MT. Rehman, F. Sameena, T. Hussain, MF. AlAjmi, D. Lai^*, and MKA. Khan*, "Investigating the binding mechanism of topiramate with bovine serum albumin using spectroscopic and computational methods," Journal of Molecular Recognition, vol. 35, no. 7, Jul 2022. (JCR 4, IF 2.137)

[6] H. Ullah, MBB. Heyat, A. Gumaei^*, Y. Lin^*,  D. Lai^*,  et. al, “An Effective and Lightweight Deep Electrocardiography  Arrhythmia Recognition Model Using Novel Special and Native Structural  Regularization Techniques on Cardiac Signal,” Journal of Healthcare Engineering, vol. 2022, Article 3408501, pp.1-18, 2022. (JCR 4, IF 2.682)

[7] M. Singh, K. Jayant, S. Bhutani, I. Hassan, FI. Hassan, D. Lai^*, S. Khan^*,  " Withania somnifera (L.) Dunal (Ashwagandha) for the possible  therapeutics and clinical management of SARS-CoV-2 infection:  Plant-based drug discovery and targeted therapy," Frontiers in Cellular and Infection Microbiology, vol. 12, Article ID. 933824, 2022  Jul. 2022 （JCR 2, IF 6.073).

[8] M Belal B. Heyat, F. Akhtar, M. Al-Sarem^*, D. Lai^*, K. Wu^*,  et al, ,  " Role of Oxidative Stress and Inflammation in Insomnia Sleep Disorder and Cardiovascular Diseases: Herbal Antioxidants and Anti-inflammatory Coupled with Insomnia Detection Using Machine Learn-ing," Current Pharmaceutical Design,  Dec. 2022 （Early Access, DOI: 10.2174/1381612829666221201161636,  JCR 4, IF 3.310).

[9] J. Rani, A. Bhargav, FI. Hassan, S. Ramachandran^*, D. Lai^*, U. Bajpai^*, "In silico prediction of natural compounds as potential multi-target inhibitors of structural proteins of SARS-CoV-2," Journal of Biomolecular Structure & Dynamics, Aug. 2021 (Early Access, DOI: 10.1080/07391102.2021.1968497).

[10] 卜雨翔，茶兴增，朱金灵，苏叶，赖大坤^*，“基于深度卷积神经网络的肥厚型心肌病自动检测模型，”生物医学工程学杂志，vol. 39, no. 2, pp.285-292, 2022.

[11] 刘铭浩，FI. Hassan，肖雨晴，王栩，胡子然，赖大坤^*，“基于分子对接与动力学模拟的用于治疗新型冠状病毒肺炎的中药活性成分虚拟筛选研究，”生物医学工程学杂志，vol. 30, no.5 , pp.10051014-, 2022.

Conference Papers会议论文：

[1]  Z. Hou, H. An, L. He, E. Li, D. Lai^*, "Super-Resolution Reconstruction Algorithm for Terahertz Images"[C], 2022 IEEE 2^nd International Conference on  Pattern Recognition and Machine Learning (PRML 2022)，Chengdu, pp. 180-185, China.

[2]  H. An, L. He, Z. Hou, D. Lai^*, Terahertz Image Super-Resolution Reconstruction Using Unpaired Real-World Images "[C], 2022 IEEE 2^nd International Conference on  Pattern Recognition and Machine Learning (PRML 2022)，Chengdu, pp. 193-198, China.

[3]  X. Fan, T. Kang, R. Luo, D. Lai^*, "Two-Dimensional Deep Learning Based Classification of Sleep Stages with Time-Frequency Maps of Single-Lead EEG Segment"[C], 2022 IEEE 2^nd International Conference on  Pattern Recognition and Machine Learning (PRML 2022)，Chengdu, pp. 211-215, China.

[4]安红宇，茶兴增，冯天琦，番雄彬，李恩，赖大坤^*, "基于双路微波源的太赫兹连续波快速三维层析成像"[C], 第十七届全国电波传播学术讨论年会，2022，延安, 中国.

[5] 冯天琦，石玉，李恩，安红宇，茶兴增，赖大坤^*,"太赫兹连续波层析成像中的结构散射特性研究"[C], 第十七届全国电波传播学术讨论年会，2022，延安, 中国.

2021年 Journal Papers期刊论文：

[1] Md Belal Bin Heyat, Faijan Akhtar, Masood Hasan Khan, Najeeb Ullah, Ijaz Gul, Haroon Khan^*, Dakun Lai^*,  “Detection,  Treatment Planning, and Genetic Predisposition of Bruxism:  A Systematic Mapping Process and Network Visualization Technique” in  CNS & Neurological Disorders - Drug Targets, vol. 20, no.8, pp. 755-775, Oct. 2021. (JCR 2, IF 4.388)

[2] FI. Khan, T. Kang, H. Ali, D. Lai^*,  “Remdesivir Strongly Binds to RNA-Dependent RNA Polymerase, Membrane  Protein, and Main Protease of SARS-CoV-2: Indication From Molecular  Modeling and Simulations”, Frontiers in Pharmacology, vol. 12, Article 710778, Jul. 2021. (JCR 2, IF 5.810)

[3] D. Lai^*,  X. Fan, Y. Zhang and W. Chen, "Intelligent and Efficient Detection of  Life-Threatening Ventricular Arrhythmias in Short Segments of Surface  ECG Signals," in IEEE Sensors Journal. vol. 21, no. 13, pp. 14110-14120, Jul. 2021. (JCR 3, IF 3.301)

[4] Y. Bu, M. F. U. Hassan and D. Lai^*, "The Embedding of Flexible Conductive Silver-Coated Electrodes into ECG Monitoring Garment for Minimizing Motion Artefacts," in IEEE Sensors Journal. vol. 21, no. 12, pp. 14454-14465, Jul. 2021. (JCR 3, IF 3.301)

[5] FI. Khan, HH. Song, F. Hassan., J. Feng, LX. Tang, D. Lai^*,  F. Juan*, "Impact of amino acid substitutions on the behavior of a  photoactivatable near infrared fluorescent protein PAiRFP1," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 253, Article ID 119572, May 2021. (JCR 3, IF 4.098)

[6] Md BB. Heyat, F. Akhtar, M.A. Ansari, A. Khan, F. Alkahtani, H. Khan^*, D. Lai^*, “Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review”， Current Drug Targets, vol. 22, no. 6, pp. 672-684, 2021. (JCR 3, IF 3.465)

[7] FI. Khan, S. Ali, W. Chen, F. Anjum, A. Shafie, I. Hassan, D. Lai^*,  “High-resolution  MD simulation studies to get mechanistic insights  into the urea-induced  denaturation of human Sphingosine kinase 1”, Current Topics in Medicinal Chemistry, vol. 21, no. 31, pp.2839-2850, 2021. (JCR 3, IF 3.295)

[8] FI. Khan, FI. Hassan, D. Lai^*, "Mechanism of pH-induced conformational changes in MurE ligase obtained from Salmonella enterica serovar Typhi," Journal of Biomolecular Structure & Dynamics, vol. 39, no. 5, pp.1898-1905, 2021.

[9] 康同舟，左润东，钟岚烽，陈文静，张恒，刘红秀，赖大坤*，“基于双密度双树复小波变换的癫痫发作期自动检测算法，”生物医学工程学杂志，vol. 38, no. 6, pp.1-10, 2021.12.

Conference Papers会议论文：

[1]  H. Ullah, Y. Bu, T. Pan, M, Gao, S. Islam, Y. Lin*, D. Lai^*, "Cardiac Arrhythmia Recognition Using Transfer Learning with a Pre-trained DenseNet"[C], 2021 IEEE 2^nd International Conference on  Pattern Recognition and Machine Learning (PRML 2021)，Chengdu, pp. 347-353, China.

2020年 Journal Papers期刊论文：

[1] D. Lai^*,   Y. Bu, Y. Su, X. Zhang and C. Ma, "Non-Standardized Patch-Based ECG   Lead Together With Deep Learning Based Algorithm for Automatic  Screening  of Atrial Fibrillation," in IEEE Journal of Biomedical and Health Informatics, vol. 24, no. 6, pp. 1569-1578, June 2020. (JCR 2, IF 5.772)

[2] FI. Khan , D. Lai^*, Anwer R, et al. "Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer," Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 35, no.1, pp. 172-186, Jan. 2020. (JCR 2, IF 4.673)

[3] FI. Khan, P. Gupta, AM. Asiri, D. Lai^*, et al., "Mechanistic insights into the urea-induced denaturation of human sphingosine kinase 1," in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES，vol.161, pp. 1496-1505, Oct. 2020. (JCR 2, IF 6.953)

[4] FI. Khan, F. Hassan, R. Anwer, F. Juan, and D.Lai ^*,  "Comparative Analysis of Bacteriophytochrome Agp2 and Its Engineered  Photoactivatable NIR Fluorescent Proteins PAiRFP1 and PAiRFP2," Biomolecules, vol. 10, no. 9, pp.1286, 2020. (JCR 2, IF 4.879)

[5] D. Lai^*,  X. Zhang, W. Chen, H. Zhang, T. Kang, H. Yuan, L. Ding, "Channel-Wise  Characterization of High Frequency Oscillations for Automated  Identification of the Seizure Onset Zone," in IEEE Access, vol. 8, pp. 45531-45543, 2020. (JCR 2, IF 3.745)    

[6] D. Lai^*,  Y. Bu, Y. Su, X. Zhang and C. Ma, "A Flexible Multilayered Dry  Electrode and Assembly to Single-Lead ECG Patch to Monitor Atrial  Fibrillation in a Real-Life Scenario," in IEEE Sensors Journal, vol. 20, no. 20, pp. 12295-12306, Oct.15, 2020. (JCR 3, IF 3.301)

[7] MBB. Heyat, D. Lai*, et al., "A Novel Hybrid Machine Learning Classification for the Detection of Bruxism Patients Using Physiological Signals," in Applied Sciences-Basel, vol. 10, no. 21, Article ID. 7410, Nov., 2020. (JCR 3, IF 2.679)

[8] Hassan F, Khan F I, Song H, Lai D.^*,   et al. Effects of reverse genetic mutations on the spectral and   photochemical behavior of a photoactivatable fluorescent protein   PAiRFP1," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 228, Article ID. 117807, Mar. 2020. (JCR 3, IF 3.232)

Conference Papers会议论文：

[1]  X. Fan, Y. Bu, D. Lai^*. “A Neural-Network Model for Deriving Analogous Three-vector ECGs of S-ICD from Standard Nine-lead ECGs”[C]， 2020 International Conference on Pattern Recognition and Machine Learning (PRML 2020), Chengdu, China.

[2] D. Lai^*, Y. Zhang and X. Zhang, "Single Lead ECG-based Ventricular Repolarization Classification for Early Identification of Unexpected Ventricular Fibrillation*," 2020 42^nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 2020, pp. 5567-5570.

[3]   D. Lai^*, L. Mao, Q. Xu and J. Li, "A Novel Reconstruction Method with Time Reversal Algorithm and Evaluations for Photoacoustic Tomography," 2020 42^nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 2020, pp. 1923-1926.

[4]  D. Lai^*, F. Ding, C. Xie and Y. Zhang, "An Adaptive Respiratory Motion Compensation Algorithm with Singular Value Decomposition for Intracardiac Catheter Tracking*,"2020 42^nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 2020, pp. 5065-5068.

2019年 Journal Papers期刊论文：

[1] D. Lai^*,  X. Zhang, Y. Bu, Y. Su and C. Ma, "An Automatic System for Real-Time  Identifying Atrial Fibrillation by Using a Lightweight Convolutional  Neural Network," in IEEE Access, vol. 7, pp. 130074-130084, 2019. (JCR 2, IF 4.098)

[2] D. Lai^*,   Y. Zhang, X. Zhang, Y. Su and M. B. Bin Heyat, "An Automated Strategy  for Early Risk Identification of Sudden Cardiac Death by Using Machine  Learning Approach on Measurable Arrhythmic Risk Markers," in IEEE  Access, vol. 7, pp. 94701-94716, 2019. (JCR 2, IF 4.098)

[3] D. Lai^*,  X. Zhang, F. Ma, Z. Chen, et al., "Automated Detection of High   Frequency Oscillations in Intracranial EEG Using the Combination of   Short-Time Energy and Convolutional Neural Networks," in IEEE Access, vol. 7, pp. 82501-82511, 2019. (JCR 2, IF 4.098)

[4] MBB. Heyat, D. Lai^*,  FI. Khan and Y. Zhang, "Sleep Bruxism Detection Using Decision Tree   Method by the Combination of C4-P4 and C4-A1 Channels of Scalp EEG," in IEEE Access, vol. 7, pp. 102542-102553, 2019. (JCR 2, IF 4.098)

[5] D. Lai^*,   MBB. Heyat, FI. Khan and Y. Zhang, "Prognosis of Sleep Bruxism  Using  Power Spectral Density Approach Applied on EEG Signal of Both  EMG1-EMG2  and ECG1-ECG2 Channels," in IEEE Access, vol. 7, pp. 82553-82562, 2019. (JCR 2, IF 4.098)

Conference Papers会议论文：

[1]    D. Lai^*, X. Zhang, Y. Zhang and M. B. Bin Heyat, "Convolutional Neural Network Based Detection of Atrial Fibrillation Combing R-R intervals and F-wave Frequency Spectrum *,"2020 41^st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany, 2019, pp. 4897-4900.

[2]  D. Lai^*, X. Fan and Q. Chen, "A Numerical Evaluation of Multi-Lead Subcutaneous Implantable Cardioverter Defibrillator for Low Energy and Less Damage in Swine*," 2020 41^st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany, 2019, pp. 4889-4892.

[3]  K. Ma, D. Lai^*, et al., "Automatic detection of High Frequency Oscillations (80-500Hz) based on Convolutional Neural Network in Human Intracerebral Electroencephalogram *," 2020 41^st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany, 2019, pp. 5133-5136.

[4]   Muhammad Faiz ul Hassan, Dakun Lai^*, Yuxiang Bu, "Characterization of Single Lead Continuous ECG Recording with Various Dry Electrodes," 2019 3^rd International Conference on Computational Biology and Bioinformatics, Nagoya, Japan, 2019, pp.76-79.

 

2018年及之前

Journal Papers期刊论文：

[1]   Q. Xu, B. Chen, P. Li, J. Liu, Dakun Lai^*, “Piezoelectric Micromachined Ultrasonic Transducers for Photoacoustic Imaging: Modeling and Simulation of Structural P arameters on Receiving Performance," X-Acoustics: Imaging and Sensing, 2015.

[2]  Lai D, Sun J, Li Y, He B.^*, "Usefulness of ventricular endocardial electric reconstruction from body surface potential maps to noninvasively localize ventricular ectopic activity in patients," Phys. Med. Biol., vol. 58, no. 11, pp.3897-3909, 2013. (UMN)

[3] Y. Long, Lai D., Sun J, He B.^*, "Noninvasive Cardiac Activation Imaging of Premature Ventricular Contractions in Human Patients," Circulation, vol. 126, no. 21, Nov. 2012. (UMN)

[4]  Lai D, Liu C, Eggen MD, Iaizzo PA, He B.^* , "Localization of endocardial ectopic activity by means of noninvasive endocardial surface current density reconstruction," Phys. Med. Biol., vol. 56, no.13, pp.4161-4176, 2011. (UMN)

[5]    D. Lai, C. Liu, M. D. Eggen, P. A. Iaizzo and B. He^*, "Equivalent Moving Dipole Localization of Cardiac Ectopic Activity in a Swine Model During Pacing," in IEEE Transactions on Information Technology in Biomedicine," vol. 14, no. 6, pp. 1318-1326, Nov. 2010. (UMN)

Conference Papers会议论文：

[1]    D. Lai^*, Z. Kan, W. Chen and H. Zhang, "High Frequency Oscillations Detection in Patients Combining Wavelet Decomposition and Back Propagation Neural Network*," 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS), Cleveland, OH, 2018, pp. 1-4.

[2]    L. Mao, D. Lai^*, Q. Xu and C. Xie, "Photoacoustic imaging: A potential new tool for diagnosing vasculogenic erectile dysfunction," 2016 9th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI), Datong, 2016, pp. 1365-1369.

[3]    H. Zhang, D. Lai^*, C. Xie, H. Zhang and W. Chen, "Directed-transfer-function based analysis for epileptic prediction," 2016 9th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI), Datong, 2016, pp. 1487-1491.

[4]    J. Liu, L. Mao, D. Lai^* and G. Liu, "A Novel Reconstruction Method of Magnetoacoustic Tomography with Magnetic Induction Based on the Amplitude of Lorentz Force," 2016 3rd International Conference on Information Science and Control Engineering (ICISCE), Beijing, 2016, pp. 88-90.

[5]    Q. Xu and D. Lai^*, "Piezoelectric micromachined ultrasonic transducers: Modeling and simulation of structural parameters on transmitting performance," 2015 IEEE Advanced Information Technology, Electronic and Automation Control Conference (IAEAC), Chongqing, 2015, pp. 648-652.

[6]    D. Lai^*, P. Li and Q. Xu, "A multi-criteria evaluation method for assessing the defibrillation outcome of different electrode placements in swine," 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, 2015, pp. 4507-4510.

[7]    D. Lai^*, F. Zhang and C. Wang, "A real-time QRS complex detection algorithm based on differential threshold method," 2015 IEEE International Conference on Digital Signal Processing (DSP), Singapore, 2015, pp. 129-133.

[8]    P. Li, D. Lai^*, F. Zhang and T. Feng, "Numerical modeling and simulation based on finite element method for internal cardiac defibrillation in a human torso," 2014 7th International Conference on Biomedical Engineering and Informatics, Dalian, 2014, pp. 456-460.

[9]    Fei Zhang, Pengye Li, Fan Jiang and Dakun Lai, "A shockable rhythm detection algorithm for automatic external defibrillators by combining a slope variability analyzer with a band-pass digital filter," 2014 IEEE Workshop on Electronics, Computer and Applications, Ottawa, ON, 2014, pp. 828-831.

[10] D. Lai, C. Liu, M. D. Eggen, P. A. Iaizzo and B. He^*, "Cardiac source localization by means of a single moving dipole solution during endocardial pacing in an animal model," 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, 2009, pp. 1778-1780. (UMN)

[11] Z. Fang, D. Lai, X. Ge and X. Wu^*, "Successive ECG telemetry monitoring for preventing sudden cardiac death," 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, 2009, pp. 1738-1741.(UMN)

[12] X. Ge, D. Lai, X. Wu and Z. Fang^*, "A novel non-model-based 6-DOF electromagnetic tracking method using non-iterative algorithm," 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, 2009, pp. 5144-5117.(UMN)

[13] D. Lai, T. Cao and Z. Fang^*, "Modeling and Simulation of Three Orthogonal Transthoracic Electrical-Fields for Localization Method of Intracardiac Catheter," 2008 2nd International Conference on Bioinformatics and Biomedical Engineering, Shanghai, 2008, pp. 1461-1463. (Fudan)

[14] X. Ge, D. Lai, X. Wu and Z. Fang^*, "A Real-Time Continuous ECG Transmitting Method through GPRS with Low Power Consumption," 2008 2nd International Conference on Bioinformatics and Biomedical Engineering, Shanghai, 2008, pp. 556-559.(Fudan)

[15] D. Lai and Z. Fang^*, "Real-Time Remote Monitoring of Out-of-Hospital Patients Especially with High Risk Heart Diseases," 2007 IEEE/ICME International Conference on Complex Medical Engineering, Beijing, 2007, pp. 332-335.(Fudan)