Lulu Cai

Doctor of Engineering

With Certificate of Graduation for Doctorate Study

Recommended Ph.D.Supervisor

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CDDS Lab > Scientific Research > Paper Publications

AML-targeted metal-polyphenol nanoplatform induces ferroptosis-ICD cascade for antitumor immunity boosting

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Affiliation of Author(s):[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Hematol, Chengdu...
Journal:Advanced Science
Key Words:acute myeloid leukemia; immunosuppression; metal-polyphenol nanoplatform; shikonin; targeted ...
Abstract:Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and immunosuppressive tumor
microenvironment (iTME). We developed a ferritin-based nanoplatform (Fe-SH@Fn) co-delivering shikonin (SH) and Fe3 + to synergistically induce ferroptosis and activate immunogenic cell death (ICD). Ferritin, a ligand for CD71, which is overexpressed
on AML cells, enables tumor targeting and encapsulates Fe-SH formed by coordination between SH and Fe3 + . In AML cells, high intracellular glutathione triggers Fe-SH@Fn disassembly: Fe3 + reduces to Fe2 + to drive Fenton ...
Volume:13
Issue:27
Page Number:e20544
ISSN No.:2198-3844
Translation or Not:no

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