陈琨

个人信息Personal Information

教授 博士生导师

性别:男

毕业院校:清华大学

学历:博士研究生毕业

学位:工学博士学位

在职信息:在职人员

所在单位:光电科学与工程学院

入职时间:2022-03-01

学科:光学工程

办公地点:四号科研楼B424

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Publications/论文

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Full publication list

(|| - equal contribution, * - corresponding author(s))



2024

§  J. Yan, Y. He, K. Chen*. “Excitation spectral microscopy for highly multiplexed intracellular imaging via quasi-blind unmixing”. ACS Photonics. 11, 3454, 2024. [Virtual special issue Rising Stars in Photonics]

2023

§  Fanfan Zhai, Li Hao, Xiaomin Chen, Ting Jiang, Qianhong Guo, Liping Xie, Ying Ma, Xiaobo Du, Zhiqin Zheng, Kun Chen*, Jun FAN*. Single-molecule tracking of PprI in D. radiodurans without interference of autoblinking. Frontiers in Microbiology, 14, 1256711, 2023.

§  L. Xiang, R. Yan, K. Chen, W. Li, K. Xu*. “Single-molecule displacement mapping unveils sign-asymmetric protein charge effects on intraorganellar diffusion”. Nano Letters, 23, 1711, 2023; bioRxiv, 2023.01.26.525611.

2022

§  K. Chen*, W. Li, K. Xu*. “Super-multiplexing excitation spectral microscopy with multiple fluorescence bands”. Biomed. Opt. Express. 13, 6048, 2022.

§  Y. Zhang||, M. Lu||, T. Wu, K. Chen, Y. Feng, W. Wang, Y. Li, H. Wei*. “Delay-Spectral Focusing Dual-Comb Coherent Raman Spectroscopy for Rapid Detection in High-Wavenumber Region”. ACS Photonics. 9, 1385, 2022. [Cover story]

§  R. Yan, K. Chen, and K. Xu*. “SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport.” Developmental Cell. 57, 512, 2022.

§  A. Choi, H. Park, K. Chen, R. Yan, W. Li and K. Xu*. “Displacement statistics of unhindered single molecules show no enhanced diffusion in enzymatic reactions.” J. Am. Chem. Soc. 144, 4839, 2022.

§  K. Chen, R. Yan, L. Xiang, K. Xu*, "Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing," Proc. SPIE PC11971, High-Speed Biomedical Imaging and Spectroscopy VII, PC119710A, 2022.

2021

§  K. Chen, R. Yan, L. Xiang, K, Xu. “Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing”. Light: Science & Applications. 10, 2021. 

          Accompanying reports about this work: 

          Bioengineer, “Excitation spectral microscopy

           Phys Org. “Integrate multi-target imaging and quantitative biosensing

§  L. Xiang||, K. Chen||, K. Xu*. “Single molecules are your quanta: A bottom-up approach toward multidimensional super-resolution microscopy”. ACS Nano. 15, 12483, 2021. 

2020

§  L, Xiang||, K. Chen||, R. Yan, W. Li, K, Xu. “Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity”. Nature Methods, 17, 524, 2020. 

§  R. Yan, K. Chen, and K. Xu. “Probing nanoscale diffusional heterogeneities in cellular membranes through multidimensional single-molecule and super-resolution microscopy.” J. Am. Chem. Soc. 142, 18866, 2020.

§  T. Wu, K. Chen, H. Wei, Y. Li*. “Repetition frequency modulated fiber laser for coherent anti-Stokes Raman scattering”. Opt. Lett. 45, 407, 2020.

2019

§  T. Wu, K. Chen, H. Zhao, W. Zhang, Y. Li, H. Wei*. “Flexible dual-soliton manipulation for coherent anti-Stokes Raman scattering spectroscopy”. Optics Express. 26, 26001, 2019.

2017

§  K. Chen, T. Wu, T. Chen, T. Zhou, H. Wei, Y. Li*. “Spectral focusing dual-comb coherent anti- Stokes Raman spectroscopic imaging”. Opt. Lett. 42, 3634, 2017.

§  K. Chen, T. Wu, Y. Li, H. Wei*. “Quantitative identification of chemical compounds by dual-soliton based coherent anti-Stokes Raman scattering spectroscopy”. Opt. Commun. 404, 177, 2017.

§  H. Yang, H, Wei, K. Chen, Y. Li*, S. Zhang. “Simply-integrated dual-comb spectrometer via tunable repetition rates and avoiding selfreferencing”. Optics Express 25, 8063, 2017.

§  K. Chen*, T. Wu, T. Chen, H. Wei, Y. Li. “Dual-comb Spectral focusing Coherent anti-Stokes Raman spectroscopy”. CLEO: Science and Innovations. Optical Society of America, SW1M. 4, 2017.

2016

§  K. Chen, T. Wu, H. Wei, Y. Li*. “Dual-soliton Stokes based background-free CARS spectroscopy and microscopy”. Opt. Lett. 41, 2628, 2016.

§  K. Chen, T. Wu, T. Zhou, H. Wei, Y. Li*. “Cascaded dual-soliton pulse Stokes for broadband Coherent Anti-Stokes Raman Spectroscopy”. IEEE Photonics Journal. 8, 1, 2016.

§  K. Chen, T. Wu, H. Wei, T. Zhou, Y. Li*. “Quantitative chemical imaging with background-free multiplex coherent anti-Stokes Raman scattering by dual-soliton Stokes pulses”. Biomed. Opt. Express. 10, 3927, 2016.

§  T. Zhou, K. Chen, H. Wei, Y. Li*. “Improved method for rapid shape recovery of large specular surfaces based on phase measuring deflectometry”. Applied optics 55, 2760, 2016.

§  T. Zhou, K. Chen, H. Wei, Y. Li*. “Improved system calibration for specular surface measurement by using reflections from a plane mirror”. Applied optics 55, 7018, 2016.

§  F. Meng, K. Chen, T. Zhou, T. Wu, H. Wei, Y. Li*. “Point-specific self-calibration for improved characterization of thickness distribution”. Optical Engineering 55, 084102, 2016.

§  H. Yang, H, Wei, H, Zhang, K. Chen, Y. Li, V. O. Smolski, K. L. Vodopyanov*. “Performance estimation of dual-comb spectroscopy in different frequency-control schemes”. Applied optics 55, 6321, 2016.

§  K. Chen*, T. Wu, H. Wei, Y. Li. “Background-free coherent anti-stokes Raman spectroscopy by all-fiber-generated dual-soliton as Stokes pulse”. CLEO: Science and Innovations. Optical Society of America, SF1O. 3, 2016.

§  T. Zhou, K. Chen, H. Wei, Y. Li*. “3D shape reconstruction of specular surfaces by using phase measuring deflectometry”. OTA, SPIE, 2016.

2015

§  K. Chen*, T. Wu, H. Wei*, X. Wu, Y. Li. “High spectral specificity of local chemical components characterization with multichannel shift-excitation Raman spectroscopy”. Sci. Rep. 5, 13952, 2015 (*Corresponding author). 

§  K. Chen, H. Wei*, H. Zhang, T. Wu, Y. Li. “A Raman peak recognition method based automated fluorescence subtraction algorithm for retrieval of Raman spectra of highly fluorescent samples”. Ana. Methods, 7, 2770, 2015.

§  F. Meng, Y. Li*, X. Wu, K. Chen, H. Wei, X. Wang. “Improved full-field rotating analyzer ellipsometry method for ultrathin film characterization”. Optical Engineering 54, 084108, 2015.

2014

§  K. Chen*, H. Zhang, H, Wei, Y. Li. “Improved Savitzky–Golay-method-based fluorescence subtraction algorithm for rapid recovery of Raman spectra”. Applied optics 53, 5559, 2014.

2013

§  K. Chen, Y. Liang*, Y. Zhang. “Study on reflection of human skin with liquid paraffin as the penetration enhancer by spectroscopy”. Journal of Biomed. Opt. 18, 105001, 2013.

 §  K. Chen, Y. Liang*, W. Zhu, X. Sun, T. Wang. “Simulation of temperature distribution in skin under laser irradiation with different wavelengths”. Optik 125, 1676, 2013.